Abstract
                                                                        The advent of digital pathology presents opportunities for computer  vision for fast, accurate, and objective solutions for histopathological images and aid in knowledge discovery. This work uses deep  learning to predict genomic biomarkers - TP53 mutation, PIK3CA  mutation, ER status, PR status, HER2 status, and intrinsic subtypes,  from breast cancer histopathology images. Furthermore, we attempt  to understand the underlying morphology as to how these genomic  biomarkers manifest in images. Since gene sequencing is expensive,  not always available, or even feasible, predicting these biomarkers  from images would help in diagnosis, prognosis, and effective treatment planning. We outperform the existing works with a minimum  improvement of 0.02 and a maximum of 0.13 AUROC scores across  all tasks. We also gain insights that can serve as hypotheses for further experimentations, including the presence of lymphocytes and  karyorrhexis. Moreover, our fully automated workflow can be extended to other tasks across other cancer subtypes.