Abstract

The variations in the intensity scale in Magnetic Resonance Images pose a problem for many tasks and Intensity Standardization (IS) aims to solve this problem. Existing methods generally use landmark values of the image histogram and match it to a standard scale. The landmarks are often chosen to be percentiles from different segmented tissues. We propose a method for IS in which tissue information (via segmentation) is needed during training but not during testing by using landmark propagation. A KL divergence-based technique is employed for identifying volumes from the training set, which are similar to a given non-standardized testing volume. The landmarks from the similar volumes are then propagated to the given test volume. Evaluation of the proposed method on 24 MRI volumes from 3 different scanners shows that the IS results are better than L4 and at par with a method which uses prior segmentation, to get percentile-based land-marks. The proposed method aids speeding up and expanding the scope of IS to volumes with no tissue information

Abstract

Cardiac motion analysis from B-mode ultrasound sequence is a key task in assessing the health of the heart. The paper proposes a new methodology for cardiac motion analysis based on the temporal behaviour of points of interest on the myocardium. We define a new signal called the Temporal Flow Graph(TFG) which depicts the movement of a point of interest over time. It is a graphical representation derived from a flow field and describes the temporal evolution of a point. We prove that TFG for an object undergoing periodic motion is also periodic. This principle can be utilized to derive both global and local information from a given sequence. We demonstrate this for detecting motion irregularities at the sequence, as well as regional levels on real and synthetic data. A coarse localisation of anatomical landmarks such as centres of left/right cavities and valve points is also demonstrated using TFGs.

Abstract

Color fundus photographs of 2252 eyes from1126 subjects were collected from 2 centers: Aravind Eye Hospital,Madurai and Coimbatore, India. The images of 1926 eyes (963 subjects) were used to train an automated image analysis-based system,which was developed to provide a decision on a given fundus image.A total of 163 subjects were clinically examined by 2 ophthalmologists independently and their diagnostic decisions were recorded. The consensus decision was defined to be the clinical reference (gold standard). Fundus images of eyes with disagreement in diagnosis were excluded from the study. The fundus images of the remaining 314eyes (157 subjects) were presented to 4 graders and their diagnostic decisions on the same were collected. The performance of the system was evaluated on the 314 images, using the reference standard. The sensitivity and specificity of the system and 4 independent graders were determined against the clinical reference standard

Abstract

Circular arc Radon (CAR) transforms associate to a function, its integrals along arcs of circles. The inversion of such transforms is of natural interest in several imaging modalities such as thermoacoustic and photoacoustic tomography, ultrasound, and intravascular imaging. Unlike the full circle counterpart—the circular Radon transform—which has attracted significant attention in recent years, the CAR transforms are scarcely studied objects.In this paper, we present an efficient algorithm for the numerical inversion of the CAR transform with fixed angular span, for the cases in which the support of the function lies entirely inside or outside the acquisition circle. The numerical algorithm is noniterative and is very efficient as the entire scheme, once processed,can be stored and used repeatedly for reconstruction of images. A modified numerical inversion algorithm is also presented to reduce the artifacts in the reconstructed image which are induced due to the limited angular span.

Abstract

3D imaging modalities are becoming increasingly popular and relevant in retinal imaging owing to their effectiveness in highlighting structures in sub-retinal layers. OCT is one such modality which has great importance in the context of analysis of cystoid structures in subretinal layers. Signal to noise ratio(SNR) of the images obtained from OCT is less and hence automated and accurate determination of cystoid structures from OCT is a challenging task. We propose an auto-mated method for detecting/segmenting cysts in 3D OCT volumes. The proposed method is biologically inspired and fast aided by the domain-knowledge about the cystoid structures. An ensemble learning method-Random forests is learnt for classification of detected region into cyst region. The method achieves detection and segmentation in a unified set-ting. We believe the proposed approach with further improvements can be a promising starting point for more robust approach. This methodis validated against the training set achieves a mean dice coefficient of0.3893 with a standard deviation of 0.2987

Abstract

Saliency computation is widely studied in computer vision but not in medical imaging. Existing computational saliency models have been developed for general (natural) images and hence may not be suitable for medical images. This is due to the variety of imaging modalities and the requirement of the models to capture not only normal but also deviations from normal anatomy. We present a biologically inspired model for colour fundus images and illustrate it for the case of diabetic retinopathy. The proposed model uses spatially-varying morphological operations to enhance lesions locally and combines an ensemble of results, of such operations, to generate the saliency map. The model is validated against an average Human Gaze map of 15 experts and found to have 10% higher recall (at 100% precision) than four leading saliency models proposed for natural images. The F-score for match with manual lesion markings by 5 experts was0.4 (as opposed to 0.532 for gaze map) for our model and very poor for existing models. The model’s utility is shown via a novel enhancement method which employs saliency to selectively enhance the abnormal regions and this was found to boost their contrast to noise ratio by∼30%

Abstract

Humans display a variety of behaviors including greedy and other unexpected biases during emergency situations. In this paper, we study the effect of such behaviors on traffic patterns during an emergency situation. In particular,we assume that during an emergency there are traffic police or other personnel trying to guide the vehicles so that the traffic clearance is sped up (to minimize the human or property losses). However each individual driver agent has its own motives and biases that may slowdown such a clearing up of traffic. In particular, we assume that the traffic police use the Ford-Fulkerson Algorithm to maximize the flow in the (traffic) network and then perform an extensive agent based analysis to study the traffic patterns that arise due to a variety of human factors and biases. Through a series of experiments performed using the well-known traffic simulator SUMO we could show that: (a) Ford-Fulkerson Algorithm is indeed efficient for clearance of vehicles in such settings (b)Driver agents that do not follow the directions due to their preferences and biases lose out on an average and (c) As can be expected, having more information about the environment available via prior knowledge and/or real-time updates can offset the effect of biases to a good extent.

Abstract

In most practical problems of classifier learning, the training data suffers from the label noise. Hence, it is important to understand how robust is a learning algorithm to such label noise. This paper presents some theoretical analysis to show that many popular decision tree algorithms are robust to symmetric label noise under large sample size. We also present some sample complexity results which provide some bounds on the sample size for the robustness to hold with a high probability. Through extensive simulations we illustrate this robustness.

Abstract

Slow moving traffic in heavily populated cities, can many times result in loss of lives due to emergency vehicles not being able to reach their destination hospitals on time. Recent advances in the field of Intelligent Transportation Systems (ITS) makes it increasingly likely that vehicles in the near future will be equipped with advanced systems that allow inter vehicular communication. In this paper, we assume the usage of such a system to optimize the lane level dynamics for an emergency vehicle (EV), traversing a multi lane stretch of road under a variety of traffic settings. In particular, we present the Fixed Lane Strategy (FLS) and the Best Lane Strategy (BLS) for EV traversal and perform an extensive agent based analysis to study their strengths and weaknesses. Through a series of experiments performed using the well-known traffic simulator SUMO, we could show that: (a) BLS performs better than SUMO strategy on all traffic settings we tested. (b) BLS performs better than FLS in settings that capture real-world traffic conditions involving congestion and uncertainties while FLS performs better in well-behaved conditions and (c) BLS was found to be the best strategy for the setting calibrated using real world data (obtained from NYCDOT).

Abstract

Slow moving traffic in heavily populated cities, can many times result in loss of lives due to emergency vehicles not being able to reach their destination hospitals on time. In this paper, we assume the usage of inter vehicular communication to optimize the lane level dynamics for an Emergency Vehicle Agent (EVA), traversing a multi lane stretch of road in an urban traffic setting. In particular, we present the Fixed Lane Strategy (FLS) and the Best Lane Strategy (BLS) for EVA traversal. FLS is a simple strategy that acts as a good baseline while BLS is a sophisticated strategy that can adapt to varying traffic patterns.