Abstract

The histone methyltransferase ASH1L, first discovered for its role in transcription, has been shown to accelerate the removal of ultraviolet (UV) light-induced cyclobutane pyrimidine dimers (CPDs) by nucleotide excision repair. Previous reports demonstrated that CPD excision is most efficient at transcriptional regulatory elements, including enhancers, relative to other genomic sites. Therefore, we analyzed DNA damage maps in ASH1L-proficient and ASH1L-deficient cells to understand how ASH1L controls enhancer stability. This comparison showed that ASH1L protects enhancer sequences against the induction of CPDs besides stimulating repair activity. ASH1L reduces CPD formation at C–containing but not at TT dinucleotides, and no protection occurs against pyrimidine-(6,4)-pyrimidone photoproducts or cisplatin crosslinks. The diminished CPD induction extends to gene promoters but excludes retrotransposons. This guardian role against CPDs in regulatory elements is associated with the presence of H3K4me3 and H3K27ac histone marks, which are known to interact with the PHD and BRD motifs of ASH1L, respectively. Molecular dynamics simulations identified a DNA-binding AT hook of ASH1L that alters the distance and dihedral angle between neighboring C nucleotides to disfavor dimerization. The loss of this protection results in a higher frequency of C–>T transitions at enhancers of skin cancers carrying ASH1L mutations compared to ASH1L-intact counterparts.

Abstract

Lupus Nephritis classification has historically relied on labor-intensive and meticulous glomerular-level labeling of renal structures in whole slide images (WSIs). However, this approach presents a formidable challenge due to its tedious and resource-intensive nature, limiting its scalability and practicality in clinical settings. In response to this challenge, our work introduces a novel methodology that utilizes only slide-level labels, eliminating the need for granular glomerular-level labeling. A comprehensive multi-stained lupus nephritis digital histopathology WSI dataset was created from the Indian population, which is the largest of its kind. LupusNet, a deep learning MIL-based model, was developed to classify LN subtypes. The results underscore its effectiveness, achieving an AUC score of 91.0%, an F1 score of 77.3%, and an accuracy of 81.1% on our dataset in distinguishing membranous and diffused classes of LN

Abstract

Manuguru, a historic coal mining hub in India's Godavari Valley Coalfield, embodies the intricate connections between resource extraction and its wide-ranging impacts. For over a century, mining has carved into the land, leaving a legacy beyond mere geographic alterations. It has reshaped ecosystems, reshuffled communities, and fueled socio-economic changes, often along lines of caste and ethnicity. This study delves into this transformative process through a geospatial analysis of land use and land cover (LULC) changes from 1987-2020, utilizing multi-spectral/multi-temporal Landsat satellite imagery. With a focus on mining's impact, advanced band spatial indices which are coupled with visual interpretation, unveil eight distinct land cover categories: agricultural land, barren land, forest, mining sites, built-up areas, rivers, stagnant water bodies, and dried water bodies, which provide a quantitative understanding of temporal dynamics. Beyond the geographical, field work delves into the human story. We explore the socio-economic realities of Manuguru, examining how mining has intensified existing divisions and fostered caste-based tensions. We further investigate how public policies intended for development might have inadvertently contributed to spatial segregation. By integrating geospatial insights with social realities, this study underscores the complex interplay between extractive industries, environmental concerns, and the social fabric. Understanding these dynamics is crucial for informed decision-making toward a sustainable future for Manuguru and similar resource-rich landscapes, one that balances progress with social equity and environmental well-being.

Abstract

The current study examines the interaction between predis- posed mood, perceptual processing, and induced mood us- ing music. We conducted an experiment in which partici- pants were asked to identify stimuli at global or local (G/L) perceptual levels with four different background music con- ditions, which had different valence and arousal ratings. We used BMIS to assess current mood and PHQ-9 and GAD-7 to assess depression and anxiety, and divided the participants into two groups: distress and no distress (encompassing both disor- ders). We found a main effect of background music on mood. However, the distress group showed an overall low mood. Fur- ther, we observed an overarching effect of predisposed mood, encompassing depression and anxiety, on individuals’ transient mood experience and perceptual task performance. Individuals in the non-distress group showed a larger global-precedence effect. The results are discussed in light of emotional reactiv- ity theories and the theory of positive emotion.

Abstract

Identifying correct human postures is crucial in areas like patient care in hospitals. However, the traditional vision-based methods widely used for this purpose raise privacy concerns for the subject, and the other wearable sensor-based approaches are impractical for real-world scenarios. In this paper, we propose a contactless, privacy-conscious, and memoryefficient posture classification system based on millimeter wave (mmWave) radar. This system utilizes threedimension(3D) point-cloud data captured using Texas Instrument’s IWR1843BOOST Frequency Modulated Continuous Wave (FMCW) radar module to classify the posture of the subject. Two types of datasets are extracted from this radar data: (i) image dataset derived from the isometric view of the point-cloud data, and (ii) spatial coordinates dataset also extracted from the point-cloud data. A low-computational Tiny Machine Learning (TinyML) model is employed on the datasets for efficient implementation on embedded hardware, Raspberry Pi 3 B+. The proposed model’s parameters were quantized to 8 bits (int8), which accurately classify four postures, i.e., standing, sitting, lying, and bending, with an accuracy of 98.97% for the image data. However, to make it more computationally efficient, the int8 quantized TinyML model was trained on the spatial coordinates dataset, giving an accuracy of 96.12%. This highlights the efficiency and effectiveness of our proposed lightweight model that can be deployed on edge devices for real-world applications.

Abstract

Reconfigurable intelligent surfaces (RIS) are emerging as a promising technology for 6G networks due to their ability to shape the radio propagation environment. This ability helps to overcome propagation challenges, such as high path loss, absorption loss, etc., that are particularly needed at millimetre wave (mmWave) bands. Thus, RIS can enhance the capacity of next-generation mmWave communication networks. However, one critical aspect in the design of RIS-aided systems is channel estimation, as it involves estimating two channels (i.e., base stationRIS and RIS-user terminal) separately based on the compound channel observed by the receiver. In this paper, we address this problem by proposing an algorithm that estimates both channels separately by leveraging the advantages of sparsity of the mmWave channel. Specifically, the proposed algorithm uses the parallel factor (PARAFAC) decomposition of the tensor, which is constructed using the received signal matrices observed under different RIS phase shift configurations. Our numerical analysis shows that the proposed algorithm provides significantly smaller normalized mean square error (NMSE) than the widely used alternating least squares (ALS) algorithm, particularly when the number of RIS phase shift configurations is smaller than the number of RIS elements.

Abstract

Automated Sleep stage classification using raw single channel EEG is a critical tool for sleep quality assessment and disorder diagnosis. However, modelling the complexity and variability inherent in this signal is a challenging task, limiting their practicality and effectiveness in clinical settings. To mitigate these challenges, this study presents an end-to-end deep learning (DL) model which integrates squeeze and excitation blocks within the residual network to extract features and stacked Bi-LSTM to understand complex temporal dependencies. A distinctive aspect of this study is the adaptation of GradCam for sleep staging, marking the first instance of an explainable DL model in this domain with alignment of its decision-making with sleep expert's insights. We evaluated our model on the publically available datasets (SleepEDF-20, SleepEDF-78, and SHHS), achieving Macro-F1 scores of 82.5, 78.9, and 81.9, respectively. Additionally, a novel training efficiency enhancement strategy was implemented by increasing stride size, leading to 8x faster training times with minimal impact on performance. Comparative analyses underscore our model outperforms all existing baselines, indicating its potential for clinical usage.

Abstract

This paper studies the contextual multi-armed bandit problem with fairness and privacy guarantees in a federated setting. It proposes a collaborative algorithm, Fed-FairX-LinUCB that achieves sublinear fairness regret and can be adapted to ensure differential privacy. The key challenge is designing a communication protocol that balances privacy and regret. The proposed protocol achieves both sub-linear fairness regret and effective use of privacy budget. Experiments validates the efficacy of both Fed-FairX-LinUCB and its private counterpart, Priv-FairX-LinUCB.

Abstract

Examining limitations is a crucial step in the scholarly research reviewing process, revealing aspects where a study might lack decisiveness or require enhancement. This aids readers in considering broader implications for further research. In this article, we present a novel and challenging task of Suggestive Limitation Generation (SLG) for research papers. We compile a dataset called LimGen, encompassing 4068 research papers and their associated limitations from the ACL anthology. We investigate several approaches to harness large language models (LLMs) for producing suggestive limitations, by thoroughly examining the related challenges, practical insights, and potential opportunities. Our LimGen dataset and code can be accessed at https://github. com/arbmf/LimGen.

Abstract

This paper examines the enhancement of quadrotor efficiency through adaptive control to address the critical need for Fault-Tolerant Control (FTC) in quadrotors amidst operational uncertainties and component inefficiency. State-of-the-art adaptive FTC strategies often assume the uncertainties to be bounded by a constant a priori; however, imprecise knowledge of inertial system parameters lead to state-dependent uncertainties which do not follow such assumption. Remain unattended, statedependent uncertainties can lead to instability, especially under actuator faults. The proposed adaptive FTC offers actuator fault mitigation while tackling unknown (statedependent) uncertainties via suitably designed adaptive laws. Additionally, real-time fault detection and control allocation are used simultaneously to avoid conservative control application. The closed-loop system stability is studied analytically and the effectiveness of the proposed solution is verified on a realistic simulator in comparison to the state of the art.