Abstract

Development of software products can often result in generation of Software Development Waste (SDW). For example, developers may possibly need to rework implementations that cater to ambiguous feature stories. COVID-19 pandemic has influenced the way software development teams operate worldwide. We studied the impact of pandemic enforced work-from-home situation (PWS) on generation of SDW. As a part of a multi-year study, we surveyed 615 participants and interviewed 31 from the software industry across eight countries specializing in various domains. We observed a rise in SDWs, and were able to identify new type of SDW, and other wastes that could be reclassified into existing types of wastes.

Abstract

This work introduces Talk2BEV, a large vision-language model (LVLM) interface for bird’s-eye view (BEV) maps in autonomous driving contexts. While existing perception systems for autonomous driving scenarios have largely focused on a pre-defined (closed) set of object categories and driving scenarios, Talk2BEV blends recent advances in general-purpose language and vision models with BEV-structured map representations, eliminating the need for task-specific models. This enables a single system to cater to a variety of autonomous driving tasks encompassing visual and spatial reasoning, predicting the intents of traffic actors, and decision-making based on visual cues. We extensively evaluate Talk2BEV on a large number of scene understanding tasks that rely on both the ability to interpret free-form natural language queries and in grounding these queries to the visual context embedded into the language-enhanced BEV map. To enable further research in LVLMs for autonomous driving scenarios, we develop and release Talk2BEV-Bench, a benchmark encompassing 1000 human-annotated BEV scenarios, with more than 20,000 questions and ground-truth responses from the NuScenes dataset.

Abstract

DNA methylation and gene expression are two critical aspects of the epigenetic landscape that contribute significantly to cancer pathogenesis. Analysis of aberrant genome-wide methylation patterns can provide insights into how these affect the cancer transcriptome and possible clinical implications for cancer diagnosis and treatment. The role of tumor suppressors and oncogenes is well known in tumorigenesis. Epigenetic alterations can significantly impact the expression and function of these critical genes, contributing to the initiation and progression of cancer. The present protocol chapter presents a unified workflow to explore the role of DNA methylation in gene expression regulation in breast cancer by identifying differentially expressed genes whose promoter or gene body regions are differentially methylated using various Bioconductor packages in R environment. Functional enrichment analysis of these genes can help in understanding the mechanisms leading to tumorigenesis due to epigenetic alterations.

Abstract

Quantum states least affected by interactions with environment play a pivotal role in both foundations and applications of quantum mechanics. Known as pointer states, they surprisingly lacked a systematic description. Working within the Born-Markov approximation, we combine methods of group theory and open quantum systems and derive general conditions describing pointer states. Contrary to common expectations, they are in general different from coherent states. Thus the two notions of being “closest to the classical”—one defined by the uncertainty relations and the other by the interaction with the environment—are in general different. As an example, we study spin-spin and spin-boson models with an arbitrary central spin J.

Abstract

Computing binding affinities is of great importance in drug discovery pipeline and its prediction using advanced machine learning methods still remains a major challenge as the existing datasets and models do not consider the dynamic features of protein-ligand interactions. To this end, we have developed PLAS-20k dataset, an extension of previously developed PLAS-5k, with 97,500 independent simulations on a total of 19,500 different protein-ligand complexes. Our results show good correlation with the available experimental values, performing better than docking scores. This holds true even for a subset of ligands that follows Lipinski’s rule, and for diverse clusters of complex structures, thereby highlighting the importance of PLAS-20k dataset in developing new ML models. Along with this, our dataset is also beneficial in classifying strong and weak binders compared to docking. Further, OnionNet model has been retrained on PLAS-20k dataset and is provided as a baseline for the prediction of binding affinities. We believe that large-scale MD-based datasets along with trajectories will form new synergy, paving the way for accelerating drug discovery.

Abstract

Living organisms are required to sense the environment accurately in order to ensure appropriate responses. The accuracy of estimating the environmental input is severely limited by noise stemming from inherent stochasticity of the chemical reactions involved in signaling pathways. Cells employ multiple strategies to improve the accuracy by tuning the reaction rates, for instance amplifying the response, reducing the noise etc.. However, the pathway also consumes energy through incorporating ATP in phosphorylating key signaling proteins involved in the reaction pathways. In many instances, improvements in accuracy elicit extra energetic cost. For example, higher deactivation rate suppresses the basal pathway activity effectively amplifying the dynamic range of the response which leads to improvement in accuracy. Higher deactivation rate also enhances the energy dissipation rate. Here, we employed a theoretical approach based on thermodynamics of information to explore the role of accuracy and energetic cost in the performance of a Mitogen Activated Protein Kinase signaling system. Our study shows that the accuracy-energy trade-off can explain the optimality of the reaction rates of the reaction pathways rather than accuracy alone. Our analysis elucidates the role of interplay between accuracy and energetic cost in evolutionary shaping of the parameter space of signaling pathways.

Abstract

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Abstract

This research paper presents a novel low computational approach for navigating a micro UAV (Unmanned Aerial Vehicle) through narrow passages using only its onboard camera feed and a PID control system. The proposed method uses edge detection and homography techniques to extract the key features of the passage from the camera feed, and then employs a tuned PID controller to guide the UAV through and out of the passage while avoiding collisions with the walls. To evaluate the effectiveness of the proposed approach, a series of experiments were conducted using a micro-UAV navigating in and out of a custom-built test environment (constrained rectangular box). The results demonstrate that the system is able to successfully guide the UAV through the passages while avoiding collisions with the walls

Abstract

There is an emerging consensus that the future of intelligent and energy efficient homes is automation and cloud control. This paper presents a novel infrastructural concept using smart ceiling tiles and an energy-harvesting Bluetooth Low Energy (BLE) switch to control home appliances. The switch location is determined using trilateration of the signals received by the tiles installed in different rooms. In this paper, we localized the switch among three rooms separated by a brick wall by analyzing the received signal strength indicator (RSSI) values captured by three tiles located in three rooms. The tiles are powered with DC power using the support rails, thus minimizing wiring for power delivery. We used different machine learning classification algorithms with the received RSSI values as features for predicting the location of the switch accurately. Through experimentation, we achieved high accuracy of 93% in classifying the switch position among the rooms. The integration of smart tiles in the false ceiling along with the use of an energy-harvesting BLE switch offers numerous advantages, such as reducing wiring complexity, enhancing user convenience, and aesthetic design.

Abstract

In the aftermath of earthquakes, hospital buildings are expected to remain occupiable to treat the injured. For the purpose, firstly, an appropriate structural system that ensures no or limited structural damage should be provided in such buildings; wall-frames are the recommended structural systems in hospital buildings. Secondly, it is also essential to adequately design wall-frames to help meet the preferred Occupiability seismic performance. The work presented in this paper examines the contributing factors for failure of structural elements in hospital buildings and explores structural configuration and design strategies for mitigating these failures. Nonlinear analyses studies of a typical hospital building in high seismic region in India are carried out to help provide quantitative guidelines for: (a) Structural Plan Density (SPD) of structural walls, and (b) design parameters, for achieving the preferred performance. Displacement-based limit state of structural damage adopted from traditional displacement demand estimation rules is proposed. Lateral stiffness, strength, and ductility are evaluated of study buildings, and efficacy of results obtained from nonlinear static analyses confirmed by performing nonlinear time history analyses in commercial software PERFORM 3D. Results demonstrate inadequacy of moment frame structural system in hospital buildings under strong earthquake shaking, identifies optimum overall SPD of structural walls and relative column-to-beam strength ratio of frame members, required to achieve Occupiability. A minimum 3% SPD of structural walls in Wall – Special Moment Resisting Frame (WSMRF), 4% SPD in Wall – Ordinary moment resisting frame (WOMRF) hospital buildings, and a minimum column-to-beam strength ratio (CBSR) of 2 is required in hospital buildings to attain Occupiability performance.